Congenital hypomyelination neuropathy in a lamb.
نویسندگان
چکیده
Congen ita l hypomyelinati on neu ro path y is a rare co ndi t ion in a ll spec ies , includ ing human beings. In the ve terina ry lit erature relating to domesti c a ni ma ls, the re is on ly a sing le report , whi ch in vol ved two Golde n Retriever puppies in a litt er o f seven." T he present re po rt is th e fi rst o f a co nge ni ta l hypom yeli nati on ne uropa thy in a lamb. A 2month-o ld Dorset ewe lamb was donat ed to th e Virgin ia Tech Vete rinary Teaching Hospital beca use o f incoo rd ina tio n. T he lamb was o ne of a se t of twi ns. T he lamb had had in termittent tremors a nd incoordinati on o f th e head a nd limbs since birt h. T he othe r tw in was clin ica lly normal. At ad missio n, th e lamb was a lert , a ppc tc nt, and thin and we ighed 6.3 kg. T emperature a nd pul se we re normal , but th er e was tach ypn ea (70 / m inute) and co ughing. A usc ultation of th e th orax revea led ha rsh bro nch o vesicul a r so unds over left a nd right lu ng field s. T he re was no men ace resp on se in either eye , but pupillary light reflexes we re normal. O phtha lm ic exa m ina tio n revealed small co lobo mas in both eyes. Intention tremor of th e head occ urred during preh en sion . T he lam b was a ble to stand with assis ta nce . It s ga it was a bnorma l with ataxi a a nd hyperm etria in a ll limbs. Strength a nd co nsc io us propri oception ap peared norm al in a ll four limbs. Pa te lla r reflexes wer e a bse n t bilat erall y. The results of a co m plete blood co un t were norm al. Ce re brospina l flu id sa m pled fro m th e a t lan to-occipita l and lumbosacral spaces co n ta ined increased prot ein (14 6 a nd 403 mg/dl , respecti vely) and a m ar gin al incr ease in m on onuclear cells ( 11/JlI a nd 6/JlI, res pective ly). An tibo dies aga ins t bov ine v ira l d iarrhea v irus were det ect ed in a blood sa m ple tak en at ad mission (1 : 64) a nd in a blood sa m ple tak en 3 weeks lat er (1 : 32 ). No
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ورودعنوان ژورنال:
- Veterinary pathology
دوره 30 6 شماره
صفحات -
تاریخ انتشار 1993